In 1932 Sewall Wright introduced the concept of a fitness landscape in evolutionary biology. Since then landscapes have become a key conceptual and computational tool in biology. This talk will describe some examples of landscapes in biology, drawn from protein science, evolutionary biology, systems biology, and microbiology. The main focus will be on recent efforts using an energy landscape picture to improve protein structure models from X-ray crystallography. These efforts involve calculations that were once computationally intractable but that recently have become possible with modern computers and advances in algorithms for molecular dynamics simulations.
Last modified: Monday, 09-Jul-2012 16:42:57 NZST
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