COSC348

COSC348 Lectures

Click for a PDF Date Topic Supplementary material
Lecture 01 06 July Overview of the course and assessment What's Bioinformatics?
Lecture 02 08 July DNA, RNA, proteins, genetic code HHMI animations
Lecture 03 13 July Genomes and gene regulatory networks 1st synthetic genome
Lecture 04 15 July Exact string searching algorithms (1) Algorithms with codes
(2) Suffix tree tutorial
Lecture 05 20 July Global sequence alignment Global vs. local align.
Lecture 06 22 July Local sequence alignment List of alignment tools
Lecture 07 27 July Sequence motif discovery What are DNA motifs?
Lecture 08 29 July Intro to probability theory Intro to probability &
Lecture 09 03 Aug Hidden Markov models (HMM) 1 Hidden Markov Models
Lecture 10 05 Aug Hidden Markov models (HMM) 2 by Richard A. O'Keefe (RO'K)
Lecture 11 10 Aug Phylogeny inference: introduction Phylogenetics (PLoS Biol)
Lecture 12 12 Aug Phylogeny inference: tree cost micro RNAs & phylogeny
Lecture 13 17 Aug Phylogeny inference: tree building
Lecture 14 19 Aug Phylogeny inference: tree optimisation Genetic algorithm by RO'K
Mid-semester break
Lecture 15 31 Aug Phylogeny inference: clustering Cluster analysis by RO'K
Lecture 16 02 Sep Microarrays: introduction Short video
Lecture 17 07 Sep Microarrays: gene selection Gene ontology
Lecture 18 09 Sep Microarrays: clustering, K-means 10 seconds video
Lecture 19 14 Sep Microarrays: NeuCom, PCA NeuCom free download
Lecture 20 16 Sep Microarrays: classification What's Classification?
Lecture 21 21 Sep Gene regulatory networks 1: Boole nets Nido et al.2015 FMN paper
Lecture 22 23 Sep Gene regulatory networks 2: weights Review GRN modelling by
Lecture 23 28 Sep Gene regulatory networks 3: ODE Schlitt & Brazma, BMC Bioinf.
Lecture 24 30 Sep Protein structure prediction Short video
Lecture 25 05 Oct Current challenges of bioinformatics
guest lecture by Chris Brown 		Predicting structure in
mRNA (Nucl. Acid Res., 2012)
Lecture 26 07 Oct Revision lecture Past exam papers